Free download PET Chemistry The Driving Force in Molecular Imaging By P.A. Schubiger

Authors of: PET Chemistry The Driving Force in Molecular Imaging By P.A. Schubiger

P A  Schubiger
L Lehmann
M Friebe

Table of Contents in PET Chemistry The Driving Force in Molecular Imaging By P.A. Schubiger

1 Molecular Imaging with PET – Open Questions?

P.A. Schubiger

2 Fluorine-18 Labeling Methods: Features and Possibilities

of Basic Reactions

H.H. Coenen

3 Fluorine-18 Labeling of Small Molecules:

The Use of 18F-Labeled Aryl Fluorides Derived

from No-Carrier-Added [18F]Fluoride as Labeling Precursors

F. Wuest

4 Fluorine-18 Labeling of Peptides and Proteins

H.J. Wester, M. Schottelius

5 [18F]Fluoropyridines: From Conventional Radiotracers

to the Labeling of Macromolecules

Such as Proteins and Oligonucleotides

F. Dollé

6 Production of Non-standard PET Radionuclides

and the Application of Radiopharmaceuticals Labeled

with these Nuclides

M.J. Welch, R. Laforest, J.S. Lewis

7 Carbon-11 Labeling Chemistry

Based upon [11C]Methyl Iodide

F. Wuest, M. Berndt, T. Kniess

8 68Ga-PET Radiopharmacy: A Generator-Based Alternative

to 18F-Radiopharmacy

H.R. Maecke, J.P. André

9 Microwaving in F-18 Chemistry:

Quirks and Tweaks

S. Stone-Elander, N. Elander, J.-O. Thorell,

A. Fredriksson

10 Micro-reactors for PET Tracer Labeling

S.Y. Lu, V.W. Pike

11 Synthesis Modules and Automation in F-18 Labeling

R. Krasikova

12 Pharmacological Prerequisites for PET Ligands

and Practical Issues in Preclinical PET Research

S.M. Ametamey, M. Honer

13 Positron Emission Tomography Imaging

as a Key Enabling Technology in Drug Development

T.J. McCarthy

Previous Volumes Published in This Series

Introduction:

Advancements in the field of molecular imaging, particularly through Positron Emission Tomography (PET), have paved the way for a deeper understanding of various biological processes. This article delves into a comprehensive overview of different aspects within this domain, highlighting significant contributions from experts in the field. Covering a wide range of topics, from labeling methods to technological applications, these discussions aim to shed light on current challenges and future prospects.

Section 1: Unanswered Questions in Molecular Imaging with PET (P.A. Schubiger):

P.A. Schubiger initiates the discourse by addressing the open questions surrounding Molecular Imaging with PET. This section explores the existing gaps in our understanding of the technology, emphasizing the need for ongoing research and advancements to enhance its efficacy and broaden its applications.

Section 2: Features and Possibilities of Basic Reactions in Fluorine-18 Labeling Methods (H.H. Coenen):

H.H. Coenen delves into the intricacies of Fluorine-18 labeling methods, shedding light on the features and possibilities associated with fundamental reactions. By dissecting the labeling process, this section contributes to the foundation of knowledge necessary for developing more sophisticated and precise PET radiopharmaceuticals.

Section 3: Fluorine-18 Labeling of Small Molecules Using [18F]Fluoride-Derived Aryl Fluorides (F. Wuest):

F. Wuest explores the potential of [18F]Fluoride-derived aryl fluorides as labeling precursors for small molecules. This section focuses on the synthesis of 18F-labeled aryl fluorides, providing insights into their utility in enhancing the specificity of PET radiotracers.

Section 4: Labeling Peptides and Proteins with Fluorine-18 (H.J. Wester, M. Schottelius):

H.J. Wester and M. Schottelius contribute to the discussion by addressing the challenges and opportunities associated with the Fluorine-18 labeling of peptides and proteins. This section explores innovative approaches to enhance the applicability of PET in studying larger biomolecules.

Section 5: [18F]Fluoropyridines: From Conventional Radiotracers to Macromolecules (F. Dollé):

F. Dollé delves into the transformation of [18F]Fluoropyridines from conventional radiotracers to labels for macromolecules such as proteins and oligonucleotides. This section highlights the versatility of these compounds and their potential impact on the evolving landscape of PET imaging.

Section 6: Production of Non-standard PET Radionuclides (M.J. Welch, R. Laforest, J.S. Lewis):

M.J. Welch, R. Laforest, and J.S. Lewis shift the focus to the production of non-standard PET radionuclides. This section explores the implications of utilizing unconventional radionuclides and their application in radiopharmaceuticals, broadening the scope of PET imaging.

Section 7: Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide (F. Wuest, M. Berndt, T. Kniess):

F. Wuest, M. Berndt, and T. Kniess dissect Carbon-11 labeling chemistry, particularly focusing on [11C]Methyl Iodide. This section provides valuable insights into the labeling processes involving Carbon-11, offering a complementary perspective to Fluorine-18 labeling.

Section 8: 68Ga-PET Radiopharmacy: A Generator-Based Alternative (H.R. Maecke, J.P. André):

H.R. Maecke and J.P. André present an alternative perspective on radiopharmacy by exploring 68Ga-PET, a generator-based approach. This section investigates the potential advantages and applications of 68Ga as an alternative to the commonly used 18F radiopharmacy.

Section 9: Microwaving in F-18 Chemistry: Quirks and Tweaks (S. Stone-Elander, N. Elander, J.-O. Thorell, A. Fredriksson):

S. Stone-Elander, N. Elander, J.-O. Thorell, and A. Fredriksson delve into the application of microwaving in F-18 chemistry, exploring its quirks and tweaks. This section provides a unique perspective on the role of microwaving in optimizing the efficiency of labeling reactions.

Section

S.Y. Lu and V.W. Pike shift the focus to micro-reactors, investigating their role in PET tracer labeling. This section explores the potential advantages and challenges associated with the miniaturization of reactors, offering insights into the evolving technology.

Section 11: Synthesis Modules and Automation in F-18 Labeling (R. Krasikova):

R. Krasikova explores the integration of synthesis modules and automation in F-18 labeling. This section discusses the advancements in technology that enable more efficient and reproducible production of PET radiopharmaceuticals.

Section 12: Pharmacological Prerequisites for PET Ligands (S.M. Ametamey, M. Honer):

S.M. Ametamey and M. Honer delve into the pharmacological prerequisites for PET ligands, addressing practical considerations in preclinical PET research. This section provides a crucial link between chemistry and pharmacology, emphasizing the importance of ligand characteristics in PET studies.

Section 13: PET Imaging as a Key Enabling Technology in Drug Development (T.J. McCarthy):

T.J. McCarthy concludes the discussion by highlighting the pivotal role of PET imaging as a key enabling technology in drug development. This section emphasizes the impact of molecular imaging in advancing drug research and development.

Conclusion:

This comprehensive overview of PET radiopharmaceuticals reflects the diverse and evolving nature of molecular imaging. Each section contributes valuable insights into different facets, from labeling methods to technological innovations, collectively shaping the landscape of PET research. As these discussions continue to unfold, they hold the promise of unlocking new possibilities and refining existing techniques, ultimately advancing our understanding of biological processes and contributing to the development of novel diagnostic and therapeutic solutions.

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