Free download 100 Must-Know Mechanisms in Organic Chemistry by Roman A. Valiulin

Authors of: 100 Must-Know Mechanisms in Organic Chemistry by Roman A. Valiulin

Roman A. Valiulin

Table of Contents in 100 Must-Know Mechanisms in Organic Chemistry by Roman A. Valiulin

The compendium of chemical reactions encompasses a diverse array of mechanisms, each elucidating the intricate pathways through which molecules transform. This extensive catalog delves into various facets of organic chemistry, detailing the mechanisms involved in the modification of molecular structures. Let’s embark on a comprehensive exploration of these mechanisms, which range from electrophilic additions to radical nucleophilic substitutions.

At the forefront, the Electrophilic Addition Mechanism elucidates the process by which electrophiles react with nucleophiles, leading to the addition of functional groups. Nucleophilic Substitution Mechanism, on the other hand, sheds light on the replacement of one nucleophile by another in a chemical compound. These fundamental mechanisms lay the groundwork for understanding more intricate reactions.

Aromatic Electrophilic Substitution Mechanism and Aromatic Nucleophilic Substitution Mechanism delve into reactions specific to aromatic compounds. The former details the substitution of hydrogen in an aromatic ring with an electrophile, while the latter outlines nucleophilic substitutions in aromatic compounds. Aromatic Radical Nucleophilic Substitution Mechanism further extends the exploration by incorporating radical reactions into the aromatic context.

The Elimination Mechanism elucidates reactions where functional groups are removed from a molecule, providing insight into how molecules transform by losing certain elements. Acyloin Condensation, Alkyne Zipper Reaction, Arbuzov Reaction, and Arndt‒Eistert Synthesis explore specific reactions that involve the condensation of acyloins, alkyne zipper processes, Arbuzov reactions, and the Arndt‒Eistert synthesis, respectively.

Baeyer‒Villiger Oxidation, Barton Decarboxylation, and Baylis‒Hillman Reaction exemplify diverse reactions. The former involves the oxidation of carbonyl compounds, the second centers around the decarboxylation of carboxylic acids, and the latter explores the Baylis‒Hillman reaction, a type of carbon–carbon bond-forming reaction.

The chemical landscape continues to unfold with reactions such as Beckmann Rearrangement, Benzoin Condensation, Benzyne Mechanism, and Bergman Cyclization. These reactions encompass rearrangements, condensations, and cyclizations, each offering unique insights into the dynamic world of chemical transformations.

Birch Reduction, Bischler‒Napieralski Cyclization, and Brown Hydroboration present additional facets of chemical reactivity. The Birch Reduction involves the reduction of aromatic compounds, while the Bischler‒Napieralski Cyclization showcases a cyclization reaction. Brown Hydroboration, on the other hand, focuses on hydroboration reactions catalyzed by boron compounds.

Transitioning to cross-coupling reactions, Buchwald‒Hartwig Cross Coupling, Cannizzaro Reaction, and Chan‒Evans‒Lam Cross Coupling showcase the versatility of these synthetic methods. CuAAC, or Copper-catalyzed Azide–Alkyne Cycloaddition, adds another dimension to cross-coupling reactions.

Chichibabin Amination, Claisen Condensation, and Claisen Rearrangement represent a diverse set of reactions. Chichibabin Amination involves the synthesis of amines, while Claisen Condensation and Claisen Rearrangement explore reactions involving esters and rearrangements.

Cope Elimination, Cope Rearrangement, and Criegee & Malaprade Oxidation contribute to the expansive repertoire of chemical reactions. These reactions involve eliminations, rearrangements, and oxidations, each providing unique pathways for molecular transformations.

Moving forward, Curtius Rearrangement, Darzens Condensation, and Dess‒Martin Oxidation continue the exploration. Curtius Rearrangement involves the rearrangement of acyl azides, Darzens Condensation focuses on the formation of epoxides, and Dess‒Martin Oxidation showcases an oxidation method utilizing a reagent developed by Daniel Dess and James Martin.

Diazotization (Diazonium Salt), Diels‒Alder Cycloaddition, and Di‒π‒Methane Rearrangement present a diverse array of reactions. Diazotization involves the conversion of primary aromatic amines to diazonium salts, Diels‒Alder Cycloaddition showcases a powerful synthetic tool, and Di‒π‒Methane Rearrangement explores rearrangements involving π systems.

Favorskii Rearrangement, Fischer Indole Synthesis, and Friedel‒Crafts Acylation & Alkylation further contribute to the rich tapestry of organic reactions. The Favorskii Rearrangement involves the rearrangement of α-haloketones, Fischer Indole Synthesis showcases a method for indole synthesis, and Friedel‒Crafts reactions demonstrate aromatic acylations and alkylations.

Gabriel Synthesis, Gewald Reaction, Glaser–Eglinton–Hay Coupling, and Grignard Reaction embody diverse synthetic methodologies. The Gabriel Synthesis provides a route to primary amines, Gewald Reaction involves the synthesis of thiazoles, Glaser–Eglinton–Hay Coupling showcases coupling reactions, and Grignard Reaction is a versatile tool for forming carbon–carbon bonds.

Grob Fragmentation, Haloform Reaction, Heck Cross Coupling, and Hell–Volhard–Zelinsky Reaction continue the exploration. Grob Fragmentation involves bond cleavage, Haloform Reaction showcases the formation of haloforms, Heck Cross Coupling is a powerful method for coupling olefins, and Hell–Volhard–Zelinsky Reaction focuses on the halogenation of carboxylic acids.

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