Free download Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry By Satyajit D. Sarker

Authors of: Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry By Satyajit D. Sarker

Satyajit D. Sarker

Lutfun Nahar

Table of Contents in Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry By Satyajit D. Sarker

Preface ix

1 Introduction

1.1 Role of chemistry in modern life

1.2 Physical properties of drug molecules

2 Atomic structure and bonding

2.1 Atoms, elements and compounds

2.2 Atomic structure: orbitals and electronic configurations

2.3 Chemical bonding theories: formation of chemical bonds

2.4 Electronegativity and chemical bonding

2.5 Bond polarity and intermolecular forces

2.6 Significance of chemical bonding in drug–receptor interactions

3 Stereochemistry

3.1 Stereochemistry: definition

3.2 Isomerism

3.3 Significance of stereoisomerism in determining drug action and toxicity

3.4 Synthesis of chiral molecules

3.5 Separation of stereoisomers: resolution of racemic mixtures

3.6 Compounds with stereocentres other than carbon

3.7 Chiral compounds that do not have a tetrahedral atom with four different groups

4 Organic functional groups

4.1 Organic functional groups: definition and structural features

4.2 Hydrocarbons

4.3 Alkanes, cycloalkanes and their derivatives

4.4 Alkenes and their derivatives 103

4.5 Alkynes and their derivatives

4.6 Aromatic compounds and their derivatives

4.7 Heterocyclic compounds and their derivatives

4.8 Nucleic acids

4.9 Amino acids and peptides

4.10 Importance of functional groups in determining drug actions and toxicity

4.11 Importance of functional groups in determining stability of drugs

5 Organic reactions

5.1 Types of organic reaction

5.2 Radical reactions: free radical chain reactions

5.3 Addition reactions

5.4 Elimination reactions: 1,2-elimination or b-elimination

5.5 Substitution reactions

5.6 Hydrolysis

5.7 Oxidation–reduction reactions

5.8 Pericyclic reactions

6 Natural product chemistry

6.1 Introduction to natural product drug discovery process

6.2 Alkaloids

6.3 Carbohydrates

6.4 Glycosides

6.5 Terpenoids

6.6 Steroids

6.7 Phenolics

Index

Chemistry plays a pivotal role in modern life, particularly in the realm of pharmaceuticals. Understanding the physical properties of drug molecules is crucial for their design, synthesis, and effectiveness. This knowledge is built upon the foundation of atomic structure and bonding theories.

Atoms, the building blocks of matter, combine to form elements and compounds. Their arrangement in orbitals and electronic configurations determines their behavior in chemical bonding. The concept of electronegativity guides the formation of chemical bonds, which in turn influences bond polarity and intermolecular forces. Such understanding is indispensable in elucidating drug-receptor interactions.

Stereochemistry delves into the spatial arrangement of atoms in molecules, giving rise to isomerism. Stereoisomerism, in particular, holds significance in delineating drug action and toxicity. The synthesis and separation of chiral molecules play crucial roles in drug development, especially concerning compounds with stereocenters beyond carbon.

Organic functional groups, integral to organic chemistry, define the structural and reactive characteristics of molecules. From hydrocarbons to nucleic acids, understanding these groups is vital for discerning drug actions, toxicity, and stability.

Organic reactions encompass various mechanisms, including radical, addition, elimination, substitution, hydrolysis, oxidation-reduction, and pericyclic reactions. Mastery of these reactions aids in designing synthetic pathways for drug synthesis.

Natural product chemistry is a rich source of drug discovery. Alkaloids, carbohydrates, glycosides, terpenoids, steroids, and phenolics offer diverse scaffolds for pharmaceutical development.

In this comprehensive text, we explore the intricate interplay between chemistry and pharmacology. By elucidating fundamental principles such as atomic structure, bonding, stereochemistry, functional groups, reactions, and natural product chemistry, we aim to equip readers with a deep understanding of the molecular basis of drug design and action.

Through meticulous examination of these topics, readers will gain insights into the multifaceted world of pharmaceutical chemistry. This knowledge serves as a foundation for drug discovery, synthesis, and optimization, ultimately contributing to advancements in healthcare and the betterment of human life.

This book is intended for students, researchers, and professionals in the fields of chemistry, pharmacology, and pharmaceutical sciences. Its comprehensive coverage and accessible style make it suitable for both academic study and reference in industrial settings.

In conclusion, the synthesis and application of chemical principles are indispensable in the development of pharmaceuticals. This text serves as a guide to understanding the molecular underpinnings of drug design and action, facilitating advancements in the field of pharmacology and healthcare.

File Size: 16.4 MB. Pages: 398 Please read Disclaimer.

Free download Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry By Satyajit D. Sarker

Download Link

You may also like to download “Applied Biopharmaceutics Pharmacokinetics 7e By Leo Shargel”.

Free download hundreds of chemistry books in pdf from HERE.

Please Subscribe to our Email list and get notified of our latest uploads (Books, documents) and new updates. Email Subscription Box is provided on the sidebar (for PC) and on the bottom of this post (for Android Devices).

Kindly Like, Follow and Share our social media pages so that maximum people can benefit from this public service!

Facebook   Instagram    LinkedIn    Twitter    Pinterest

P.S: If the download link(s) is/are not working, kindly drop a comment below, so we’ll update the download link for you.

Happy reading!