Organic Medicinal and Pharmaceutical Chemistry By John M. Beale (informative)
Free download Organic Medicinal and Pharmaceutical Chemistry By John M. Beale 12th Edition
12th Edition
Authors of: Organic Medicinal and Pharmaceutical Chemistry By John M. Beale 12th Edition
John M. Beale
John H. Block
Table of Contents in Organic Medicinal and Pharmaceutical Chemistry By John M. Beale 12th Edition
Preface
Contributors
CHAPTER 1
Introduction
John M. Beale, Jr. and John H. Block
CHAPTER 2
Drug Design Strategies
John H. Block
Drug Distribution
Acid–Base Properties
Computer-Aided Drug Design: Early Methods
Computer-Aided Drug Design: Newer Methods
Selected Web Pages
CHAPTER 3
Metabolic Changes of Drugs and Related Organic Compounds
Stephen J. Cutler and John H. Block
General Pathways of Drug Metabolism
Sites of Drug Biotransformation
Role of Cytochrome P450 Monooxygenases in Oxidative Biotransformations
Oxidative Reactions
Reductive Reactions
Hydrolytic Reactions
Phase II or Conjugation Reactions
Factors Affecting Drug Metabolism
CHAPTER 4
Biotechnology and Drug Discovery
John M. Beale, Jr.
Biotechnology and Pharmaceutical Care
Literature of Biotechnology
Biotechnology and New Drug Development
The Biotechnology of Recombinant DNA
Some Types of Cloning
Expression of Cloned DNA
Manipulation of DNA Sequence Information
New Biological Targets for Drug Development
Novel Drug-Screening Strategies
Processing of the Recombinant Protein
Pharmaceutics of Recombinant DNA-Produced Agents
Delivery and Pharmacokinetics of Biotechnology Products
Recombinant Drug Products
The Interleukins
Enzymes
Vaccines
Preparation of Antibodies
Genomics
Antisense Technology
Gene Therapy
Afterword
CHAPTER 5
Immunobiologicals
John M. Beale, Jr.
Cells of the Immune System
Immunity
Acquisition of Immunity
New Vaccine Technologies: Adjuvant Technology
New Vaccine Technologies: Nucleic Acid Vaccines
CHAPTER 6
Anti-infective Agents
John M. Beale, Jr.
Evaluation of the Effectiveness of a Sterilant
Alcohols and Related Compounds
Phenols and Their Derivatives
Oxidizing Agents
Halogen-Containing Compounds
Cationic Surfactants
Dyes
Mercury Compounds (Mercurials)
Preservatives
Antifungal Agents
Synthetic Antibacterial Agents
Antiprotozoal Agents
Anthelmintics
Antiscabious and Antipedicular Agents
Antibacterial Sulfonamides
Dihydrofolate Reductase Inhibitors
Sulfones
CHAPTER 7
Antimalarials
John H. Block
Stimulation of Antimalarial Research by War
Cinchona Alkaloids
CHAPTER 8
Antibacterial Antibiotics
John M. Beale, Jr.
Historical Background
Current Status
Commercial Production
Spectrum of Activity
Mechanisms of Action
Chemical Classification
Microbial Resistance
β-Lactam Antibiotics
The Penicillins
β-Lactamase Inhibitors
Cephalosporins
Monobactams
Aminoglycosides
Tetracyclines
Macrolides
Lincomycins
Polypeptides
Unclassified Antibiotics
Newer Antibiotics
New Directions in Antibiotic Discovery
CHAPTER 9
Antiviral Agents
John M. Beale, Jr.
The Classification and Biochemistry of Viruses
Classification of Viruses
Targets for the Prevention of Viral Infections—Chemoprophylaxis
The Infectious Process for a Virus
Nucleoside Antimetabolites: Inhibiting Viral Replication
Newer Agents for the Treatment of HIV Infection
CHAPTER 10
Antineoplastic Agents
Forrest T. Smith and C. Randall Clark
Introduction
Drug Classes
Antimetabolites
Antibiotics and Natural Products
Protein Kinase Inhibitors
Miscellaneous Compounds
CHAPTER 11
Agents for Diagnostic Imaging
Jeffrey J. Christoff
Radiopharmaceuticals
Contrast Agents
CHAPTER 12
Central Nervous System Depressants
Shengquan Liu
Anxiolytic, Sedative, and Hypnotic Agents
Antipsychotics
Acknowledgment
CHAPTER 13
Central Dopaminergic Signaling Agents
A. Michael Crider, Marcelo J. Nieto, and Kenneth A. Witt
Dopamine
Parkinson Disease
Antipsychotic Drugs
Future Directions
CHAPTER 14
Anticonvulsants
Matthias C. Lu
Disease States Requiring Anticonvulsant Therapy
Mechanisms of Action of Anticonvulsants
Clinically Important Anticonvulsants
Future Development of Antiepileptic Drugs
CHAPTER 15
Central Nervous System Stimulants
John M. Beale, Jr.
Analeptics
Methylxanthines
Central Sympathomimetic Agents (Psychomotor Stimulants)
Antidepressants
Miscellaneous CNS-Acting Drugs
CHAPTER 16
Adrenergic Agents
Shengquan Liu
Adrenergic Neurotransmitters
Adrenergic Receptors
Drugs Affecting Adrenergic Neurotransmission
Sympathomimetic Agents
Adrenergic Receptor Antagonists (Blockers)
Acknowledgment
CHAPTER 17
Cholinergic Drugs and Related Agents
Stephen J. Cutler
Cholinergic Receptors
Cholinergic Neurochemistry
Cholinergic Agonists
Cholinergic Receptor Antagonists
Cholinergic Blocking Agents
Parasympathetic Postganglionic Blocking Agents
Solanaceous Alkaloids and Analogs
Synthetic Cholinergic Blocking Agents
Ganglionic Blocking Agents
Neuromuscular Blocking Agents
CHAPTER 18
Drugs Acting on the Renal System
Stephen J. Cutler
Renin–Angiotensin System Inhibitors
ACE-Inhibitor Prodrugs
Angiotensin Antagonists
Angiotensin II Blockers
Renin Inhibitors
Aldosterone Antagonists
CHAPTER 19
Cardiovascular Agents
Stephen J. Cutler
Antianginal Agents and Vasodilators
Antiarrhythmic Drugs
Antihypertensive Agents
Antihyperlipidemic Agents
Anticoagulants
Synthetic Hypoglycemic Agents
Thyroid Hormones
Antithyroid Drugs
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