Free Download Fundamentals of Protein Structure and Function by Engelbert Buxbaum – Second Edition

 Fundamentals of Protein Structure and Function

Authors:

Engelbert Buxbaum

Table of Contents

Part I Proteins

1 Amino Acids

1.1 Basic Structure of Amino Acids

1.2 The Isoelectric Point

1.3 The One-Letter Code

1.4 Biological Function of Amino Acid Variety

2 Protein Structure

2.1 Primary Structure

2.1.1 Protein Sequences and Evolution

2.2 Secondary Structure

2.2.1 The -Helix

2.2.2 -Strand

2.2.3 The PII (syn.: Poly-Pro or Polypeptide II) Helix

2.2.4 Hairpin Turns 2.2.5 Rare Structures

2.2.6 Coils

2.3 Tertiary Structure

2.3.1 Classification of Proteins by Folding Pattern

2.4 Quaternary Structure

2.5 Further Aspects of Protein Structure

2.5.1 LEVINTHAL’s paradox:

2.5.2 Energetics and Kinetics of Protein Folding

2.5.3 Morpheeins

2.5.4 Molecular Chaperones and Chaperonins

2.5.5 Protein Denaturation

2.5.6 Protein Folding

2.6 Posttranslational Modifications of Proteins

2.6.1 Glycosylation

2.6.2 Glucation

2.6.3 Disulphide Bond Formation

2.6.4 Proteolysis

2.6.5 Hydroxylation

2.6.6 Phosphorylation/Dephosphorylation

2.6.7 Acetylation/Deacetylation

2.6.8 Methylation/Demethylation

2.6.9 Addition/Removal of Hydrophobic Tails

2.6.10 S-Nitrosylation.

2.6.11 ADP-Ribosylation

2.6.12 Deamidation

2.6.13 AMPylation (Adenylylation)

2.6.14 Transfer of Peptides

2.7 The Relationship Between Protein Structure and Function: Green Fluorescent Protein

3 Proteins in the Lab

Part II Enzymes

4 Enzymes Are Biocatalysts

5 Enzyme Kinetics and Mechanism

6 Inhibition and Inactivation of Enzymes

7 Hæmoglobin and Myoglobin: Cooperativity

8 Enzyme Kinetics: Special Cases

9 The Flow of Metabolites Through Metabolic Pathways

Part III Special Proteins

10 Protein Folding Diseases

11 Immunoproteins

12 Cell Skeleton 

13 Motor Proteins and Movement

14 Cell–Cell Interactions

15 Aiding in Folding: Molecular Chaperones and Chaperonins

Part IV Membrane Transport

16 Protein Transport Across Membranes

17 Vesicular Transport in Eukaryotic Cells

18 Transport of Solutes across Membranes

Appendix A: Short Biographies of Scientists Mentioned in This Book

Appendix B: List of Symbols

Appendix C: Greek Alphabet

Appendix D: The Genetic Code

Appendix E: Acronyms

Index

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