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Chemistry of Drugs by David E. Newton

Chemistry of Drugs by David E. Newton

Chemistry of Drugs by DAVID E. NEWTON

Free Download Chemistry of Drugs by David E. Newton

Chemistry of Drugs by David E. Newton

Authors:
DAVID E. NEWTON

 

Table of Contents

 

Preface

Introduction

1 UNDERSTANDING THE WAY DRUGS WORK

IN THE BODY

Early Humans Discover Drugs

Types of Drugs

How Drugs Work: Disease Prevention

How Drugs Work: Altering Mental Processes

Otto Loewi (1873–1961)

The Future of Drug Design and Development

Candace Beebe Pert (1946)

2 NATURAL PRODUCTS

The Use of Natural Products as Drugs in History

Natural Products and the Rise of Modern Chemistry

Robert Burns Woodward (1917–1979)

Microorganisms as the Source of Drugs

Marine Organisms as a Source of Drugs

Plant Products as the Source of New Drugs

Monroe Wall (1916–2002) and

Mansukhlal Wani (1925)

The Search for New Natural Product Drugs

Natural Product Research and Biodiversity

Natural Products as Dietary Supplements

The Safety of Natural Products as Drugs

3 RECOMBINANT DNA AS A NEW SOURCE OF DRUGS

Principles of Recombinant DNA

Paul Berg (1926– )

The Process of Recombinant DNA

Werner Arber (1929– )

Drugs Produced by Recombinant DNA

Pharming as a Source of Genetically Modified Drugs

Pharming and Transgenic Technology

Pros and Cons of Pharming

4 DESIGNER DRUGS

What Are Designer Drugs?

Illegal Designer Drugs

U.S. Drug Enforcement Administration

Fentanyl Analogs

Phenylethylamine Analogs

Methamphetamine

MDMA

Alexander “Sasha” Shulgin (1925)

Meperidine Analogs

Phencyclidine Analogs

GHB and Rohypnol

Guesses and Risks

5 RATIONAL DRUG DESIGN: STRUCTURE-ACTIVITY

RELATIONSHIPS AND COMBINATORIAL CHEMISTRY

Steps in the Development of a New Drug

Rational Drug Design

Structure-Activity Relationships

Elements of Structure-Activity Relationship

Drug Design

Modifications in Pharmcophores

Quantitative Structure-Activity Relationships

Louis Plack Hammett (1894–1987)

Combinatorial Chemistry

Solid-Phase Synthesis

  1. Bruce Merrifi eld (1921–2006)

Solution-Phase Synthesis

Applications of Combinatorial Chemistry

CONCLUSION

Glossary

Further Reading

Index

 

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