Chemistry of Drugs by David E. Newton
Free Download Chemistry of Drugs by David E. Newton
Chemistry of Drugs by David E. Newton
Authors:
DAVID E. NEWTON
Table of Contents
Preface
Introduction
1 UNDERSTANDING THE WAY DRUGS WORK
IN THE BODY
Early Humans Discover Drugs
Types of Drugs
How Drugs Work: Disease Prevention
How Drugs Work: Altering Mental Processes
Otto Loewi (1873–1961)
The Future of Drug Design and Development
Candace Beebe Pert (1946)
2 NATURAL PRODUCTS
The Use of Natural Products as Drugs in History
Natural Products and the Rise of Modern Chemistry
Robert Burns Woodward (1917–1979)
Microorganisms as the Source of Drugs
Marine Organisms as a Source of Drugs
Plant Products as the Source of New Drugs
Monroe Wall (1916–2002) and
Mansukhlal Wani (1925)
The Search for New Natural Product Drugs
Natural Product Research and Biodiversity
Natural Products as Dietary Supplements
The Safety of Natural Products as Drugs
3 RECOMBINANT DNA AS A NEW SOURCE OF DRUGS
Principles of Recombinant DNA
Paul Berg (1926– )
The Process of Recombinant DNA
Werner Arber (1929– )
Drugs Produced by Recombinant DNA
Pharming as a Source of Genetically Modified Drugs
Pharming and Transgenic Technology
Pros and Cons of Pharming
4 DESIGNER DRUGS
What Are Designer Drugs?
Illegal Designer Drugs
U.S. Drug Enforcement Administration
Fentanyl Analogs
Phenylethylamine Analogs
Methamphetamine
MDMA
Alexander “Sasha” Shulgin (1925)
Meperidine Analogs
Phencyclidine Analogs
GHB and Rohypnol
Guesses and Risks
5 RATIONAL DRUG DESIGN: STRUCTURE-ACTIVITY
RELATIONSHIPS AND COMBINATORIAL CHEMISTRY
Steps in the Development of a New Drug
Rational Drug Design
Structure-Activity Relationships
Elements of Structure-Activity Relationship
Drug Design
Modifications in Pharmcophores
Quantitative Structure-Activity Relationships
Louis Plack Hammett (1894–1987)
Combinatorial Chemistry
Solid-Phase Synthesis
- Bruce Merrifi eld (1921–2006)
Solution-Phase Synthesis
Applications of Combinatorial Chemistry
CONCLUSION
Glossary
Further Reading
Index
File Size: 2.88 MB. Pages: 191. Please read Disclaimer.
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